高杨

姓名:高杨

职称:副教授

 

一、教育经历

20042009清华大学生物科学与技术系理学博士

20012004厦门大学生命科学学院理学硕士

19962000厦门大学生命科学学院理学学士

 

二、工作经历

20092020 澳门永利集团3044讲师

2020-今   澳门永利集团3044副教授

 

三、研究方向(包括承担课题项目)

1 癌症侵袭和转移方面的分子机理和蛋白质组学方面的基础研究

2 乳品活性物质功能研究

 

承担课题项目:

主持国家自然科学基金四项,天津市自然科学基金一项,中央高校基本科研业务费专项资金资助一项,曾作为主要参与人和完成者参与包括国家自然科学基金重大专项,863子课题等多项重要科研项目的研究工作。

1 LMO2调控前列腺癌恶化和转移相关的信号通路与蛋白质组学研究国家自然科学基金

2 LMO2在前列腺癌恶化和转移过程中的功能及机理研究天津市应用基础及前沿技术研究计划

3 新疆双峰驼乳清蛋白抗肿瘤活性及其构效关系研究国家自然科学基金

4 驼乳清提取物通过VEGF介导的PI3K/AKT-eNOS通路促血管新生并协同抗氧化功能加速糖尿病创面愈合  国家自然科学基金面上项目

 

四、学术兼职

1 中国免疫学会会员

2 美国肿瘤研究协会成员(AACR

 

五、发表论文

1.      Zhou YK; Shen ZA; Yu H; Luo T; Gao Y*; Du PF*. Predicting lncRNAProtein Interactions With miRNAs as Mediators in a Heterogeneous Network Model. Frontiers in Genetics,2020 Jan 22;10:1341.

2.      Deng L#, Li Al#, GaoY#, Shen T, Yue HT, Miao J, Li RR, Yang J. Detection of the Bovine Milk Adulterated in Camel, Horse, and Goat Milk Using Duplex PCR. Food Analytical Methods. 2020 13: 560567.

3.      Yang J, Dou Z, Peng X, Wang H, Shen T, Liu J, Li G, Gao Y*. Transcriptomics and proteomics analyses of anti-cancer mechanisms of TR35-An active fraction from Xinjiang Bactrian camel milk in esophageal carcinoma cellClin Nutr. 2019 Oct;38(5):2349-2359.

4.      Zhao W, Li GP, Wang J, Zhou YK, Gao Y*, Du PF*.Predicting protein sub-Golgi locations by combining functional domain enrichment scores with pseudo-amino acid compositions. J Theor Biol. 2019 Jul 21;473:38-43.

5.      Miao YY, Zhao W, Li GP, Gao Y*, Du PF*. Predicting Endoplasmic Reticulum Resident Proteins Using Auto-Cross Covariance Transformation With a U-Shaped Residue Weight-Transfer Function. Front Genet. 2019 Dec 20;10:1231.

6.      Wu C, Yuan M, Gao Y*, Sun W*. LMO2 functional and transcriptional regulatory profiles in hematopoietic cells. Leuk Res. 2018 75:11-14

7.      Peng X, Yang J, Gao Y*. Proteomic Analyses of Changes in Synechococcus sp. PCC7942 Following UV-C Stress. Photochem Photobiol. 2017 93(4):1073-1080.

8.      Peng X, Ye Z, Gao Y*. Regulation of E-cadherin promoter activity by LMO2 impact on the progression and metastasis of prostate cancer.Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 29(5):385-9

9.      Du P, Wang X, Xu C, Gao Y*. PseAAC-Builder: a cross-platform stand-alone program for generating various special Chou's pseudo-amino acid compositions. Anal Biochem. 2012 425(2):117-9.

10.   Ma C#, Gao Y#, Chai G, Su H, Wang N, Yang Y, Li C, Miao D, Wu W. Djrho2 is involved in regeneration of visual nerves in Dugesia japonica. J Genet Genomics. 2010 37(11):713-23.

11.   Liu L, Li L, Ma C, Shi Y, Liu C, Xiao Z, Zhang Y, Tian F, Gao Y, Zhang J, Ying W, Wang PG, Zhang L. O-GlcNAcylation of Thr12/Ser56 in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity. J Biol Chem. 2019 Nov 8;294(45):16620-16633.

12.   Jiang K, Gao Y, Hou W, Tian F, Ying W, Li L, Bai B, Hou G, Wang PG, Zhang L. Proteomic Analysis of O-GlcNAcylated Proteins in Invasive Ductal Breast Carcinomas With and Without Lymph Node Metastasis. Amino Acids. 2016 Feb;48(2):365-74.

13.   Hu F, Wang C, Guo S, Sun W, Mi D, Gao Y, Zhang J, Zhu T, Yang S. DeltaEF1 promotes osteolytic metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression. Biochim Biophys Acta. 2011 Mar;1809(3):200-10.

14.   Sun W, Shen WW, Yang S, Hu F, Gao Y, Qiao YH, Zhu TH. Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes. J Biomed Sci. 2010 Mar 27;17(1):22.

15.   Sun W, Yang S, Shen W, Li H, Gao Y, Zhu TH. Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T-cell leukemia. Eur J Haematol. 2010 Dec;85(6):508-19.

 

六、讲授课程

1医学分子遗传学

2.  医学分子遗传学实验

3.  Medical Genetics

4.  揭开基因的奥秘

 

七、荣誉和奖励

1. 南开大学青年教师基本功大赛一等奖

2 天津市高校青年教师教学基本功竞赛优秀奖

 

八、联系方式

1通讯地址:天津市南开区卫津路94

2电话:23504334

3 E-mail gaoy@nankai.edu.cn

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