张裕英

一、 研究方向

表面增强拉曼散射(SERS)探针、细胞/组织多色成像

 

二、教育经历

 本科     1999-2003 武汉大学化学与分子科学学院   应用化学

 研究生   2003-2008 武汉大学生命科学学院         生物化学与分子生物学

 

三、科研及工作经历

 助理研究员  2008-2010 浙江大学高分子系

 博士后      2011-2014 德国奥森纳布吕克大学生物系

 postdoc            Department of Biology, University of Osnabrück

 博士后      2014-2017 德国杜伊斯堡-埃森大学化学系

 postdoc       Department of Chemistry,University of Duisburg-Essen

副教授 硕士生导师   2017.08 至今 澳门永利集团3044

 (Associate Professor,  Master's Tutor )         (School of Medicine, Nankai University)

 

四、主要科研项目

1. iRGD介导纳米载体靶向渗透小鼠乳腺癌组织的SERS成像分析,国家自然科学基金面上项目,主持 (2019-2022

2. 用于光动力与光高热联合治疗癌症的新型微胶囊的制备及作用机制研究,国家自然科学基金青年项目,主持(2010-2012

3. 调控细胞迁移与分化的梯度医用高分子材料研究,国家自然科学基金重点项目,参与(2010-2013

4. 诱导干细胞定域分化的图案化粘弹性水凝胶研究,国家自然科学基金青年项目,参与(2011-2013

 

五、代表性著作、论文情况

 论文:

1)    Xiaojie Wang, Xinxin Yuan, Kexin Fu, Chang Liu, Lu Bai, Xinchao Wang, Xiaoyue Tan, Yuying Zhang. Colorimetric analysis of extracellular vesicle surface proteins based on controlled growth of Au aptasensors. Analyst, 2020, 146(6): 2019-2028.

2)    Kexin Fu, Xiaojie Wang, Xinxin Yuan, Dekun Wang, Xue Mi, Xiaoyue Tan, Yuying Zhang. Size-Dependent Penetration of Gold Nanoprobes into Fixed Cells. ACS Omega. 2020, 6(5): 3791-3799.

3)    Lu Bai, Xiaojie Wang, Kaifu Zhang, Xiaoyue Tan, Yuying Zhang, Wei Xie. Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells. Chemical Communications. 2019, 55: 12996-9.

4)    Yuying Zhang, Xue Mi, Xiaoyue Tan, Rong Xiang. Recent progress on liquid biopsy analysis using surface-enhanced Raman spectroscopy. Theranostics. 2019, 9: 491-525.

5)    Yuying Zhang, Xin-ping Wang, Sven Perner, Agnes Bankfalvi, Sebastian Schlücker, Effect of antigen retrieval methods on non-specific binding of anti-body-metal nanoparticle conjugates on FFPE tissue, Analytical Chemistry, 2018, 90(10): 760-8.

6)    Yuying Zhang, Bernd Walkenfort, Jun Hee Yoon, Sebastian Schlücker, Wei Xie. Gold and silver nanoparticle monomers are not SERS-active: a negative experimental study with silica-encapsulated, Raman-reporter-coated metal colloids. Physical Chemistry Chemical Physics, 2015, 17, 21120-6.

7)    Yuying Zhang, Viktoria Krieger, Michael Hensel. Application of Fluorescent Nanoparticles to Study Remodeling of the Endo-lysosomal System by Intracellular Bacteria. Journal of Visualized Experiments, 2015, (95), e52058, doi:10.3791/52058.

8)    Yuying Zhang, Michael Hensel. Evaluation of nanoparticles as endocytic tracers in cellular microbiology. Nanoscale, 2013, 5, 9296-309.

9Yuying Zhang, Ling Hu, Dahai Yu, Changyou Gao. Influences of silica particles internalization on adhesion and migration of human dermal fibroblasts. Biomaterials, 2010, 31(32), 8465-74.

论著:

Yuying Zhang, Sebastian Schlücker; iSERS microscopy for tissue-based cancer diagnostics, Confocal Raman Microscopy, Springer, 01/2018: pages 347-379; ISBN: 978-3-319-75378-2, DOI:10.1007/978-3-319-75380-5_15.

 

 六、联系方式

1.通讯地址:天津南开区卫津路94号澳门永利集团3044

2. E-mailyuyingzhang@nankai.edu.cn

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