金鑫

金鑫,副教授

研究方向(脑发育障碍与离子通道疾病实验室):

大脑发育障碍的神经环路机制研究

离子通道的表观遗传调控在疾病中的作用机制研究

靶向离子通道及神经递质受体的药物研究与开发

妊娠期药物及不良环境暴露对子代发育的影响机制研究

教育经历:

2005年-2008年日本冈山大学,医齿药综合研究院,临床药学,博士学位

2003年-2005年日本冈山大学,自然科学研究院,药物科学,硕士学位

1999年-2003年哈尔滨商业大学,药学院,制药工程,学士学位

研究工作经历:

2018年-至今,南开大学,澳门永利集团3044,副教授

2014年-2018年,耶鲁大学,澳门永利集团3044,副研究科学家;客座副教授

2010年-2014年,佐治亚州立大学,生物系,博士后研究员

2009年-2010年,冈山大学,先端研究中心,研究员

承担课题项目:

国家自然科学基金面上项目

京津冀基础研究合作专项

天津市人类发育与生殖调控重点实验室开放基金项目

南开大学交叉融合科学基金项目

所属学术组织:

中国神经科学学会会员(Chinese Neuroscience Society, CNS)

中国药理学会会员(Chinese Pharmacological Society,CNPHARS)

美国神经科学学会会员(Society For Neuroscience,SFN)

美国实验生物学学会会员(Experimental Biology,EB)

日本药学学会会员(Japanese Pharmaceutical Society,JPS)

日本药理学学会会员(Japanese Pharmacological Society,JPHARS )

担任多个国际期刊副主编及特邀审稿人

发表学术文章(发表SCI期刊论文40篇):

1.      Jin X, Wu Y, Cui N, Jiang C, Li SS,Methylglyoxal-induced miR-223 suppresses rat vascular KATP channel activity by downregulating Kir6.1 mRNA in carbonyl stress. Vascular Pharmacology. In press (2020).

2.      PanY, SitaramanD, ChenN, JinX, ChenD, NitabachMN, BakerB. Sexually dimorphic neural substrates for prioritizing sleep and reproductive behaviors in Drosophila. Nature Communications .8: 154 (2017).

3.      Jin H, Li Z, Takatori S, Koyama T, Jin X, Zamami Y, Kawasaki H, Sun P. Vascular Responses to Compound 48/80 in Rat Mesenteric Vascular Beds. Canadian Journal of Physiology and Pharmacology. 2016 Jun;94(6):620-6.

4.      Sitaraman D, Aso Y, Jin X, Chen N, Felix M, Rubin GM, Nitabach M. Homeostatic control of sleep by synaptic microcircuits in the Drosophila mushroom body. Current Biology.16; 25(22):2915-27 (2015).

5.      Jin X, Li SS, Bondy B, Zhong W, Oginsky M, Yang Wu, Johnson C, Zhang S, Cui N, Jiang C. Optogenetic identification of local GABAergic signaling in the locus coeruleus. PLoS ONE. Jan 19; 11(1):e0146470 (2016).   

6.      Li SS, Wu Y, Jin X, Jiang C. The SUR2B subunit of rat vascular KATP channel is targeted by miR-9a-3p induced by prolonged exposure to methylglyoxal.American J Physiology. 308: C139–C145, (2015).   

7.      Jin X, Zhong W, Jiang C. Time-dependent modulation of GABAA-ergic synaptic transmission by allopregnanolone in locus coeruleus neurons of Mecp2-null mice. American J Physiology. 305:C1151-60 (2013).

8.      Jin X, Cui N, Zhong W, Jin XT, Jiang C. GABA-ergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice. American J Physiol. 304:844-857 (2013).

9.      Jin X, Yu L, Zhang S, Wu Y, Shi ZD, ChenXF, Yang Y, ZhangXL, JiangC. S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. J Physiol. 590:5335-5348 (2012).

10.  Yu L, Jin X, Yang Y, Cui N, Jiang C. Rosiglitazone inhibits vascular KATP channels and coronary vasodilation response to isoproterenol. Br J Pharmacol. 164: 2064-72 (2011). 

11.  Jin X, Satoh-Otonashi Y, Zamami Y, Takatori S, Hashikawa-Hobara N, Kitamura Y, Kawasaki H. New molecular mechanisms for cardiovascular disease: contribution of endothelium-derived hyperpolarizing factor in the regulation of vasoconstriction in peripheral resistance arteries.J Pharmacol Sci. 116:332-6 (2011).

12.  Jin X, Yukiko Satoh O,Zamami Y, Sun P, Simin Li, Hobara N, Kitamura Y, Kawasaki H. Endothelial modulation of agonist-induced vasoconstriction in mesenteric microcirculation. YAKUGAKU ZASSHI. 130(5):723-8 (2010).

13.  Jin X,Amitani K, Zamami Y, Hobara N, Kawamura N, Hirata T, Wada A, Kawasaki H. Ameliorative effects of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats. Journal of Ethnopharmacology. 21;128(3) (2010).

14.  Jin X, Yukiko Satoh O, Zamami Y, Hobara N, Koyama T, Sun PY, Li S, Kitamura Y, Kawasaki H. Age-related disappearance of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric vascular beds. J Pharmacol Sci. 111: 372-380 (2009).

15.  Jin X, Yukiko Satoh O, Sun P, Kawamura N, Tsuboi T, Yamaguchi Y,Ueda T, Kawasaki H.Endothelium-derived hyperpolarizing factor (EDHF) mediates endothelium-dependent vasodilator effects of aqueous extracts from Eucommia ulmoides Oliv. Leaves in rat mesenteric resistance arteries.Acta Medica Okayama. 62 (5): 319-325 (2008).

16.  Jin X, Yukiko Satoh O,Zamami Y, Sun P, Kitamura Y, Kawasaki H.Characterization of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric resistance arteries.J Pharmacol Sci. 108: 95-103 (2008).

 讲授课程:

药理学(临床与口腔专业);口腔临床药学(口腔专业);医学机能学实验(临床与口腔专业),药理学(留学生课程)

教材编辑:

《医学实验技术原理与选择》

联系方式:

通讯地址:天津市南开区卫津路94号澳门永利集团3044

 E-mail:xin.jin@nankai.edu.cn

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