姓名：胡耀中

职称：副研究员

一、教育经历

2014.09-2018.01比利时布鲁塞尔自由大学，生物工程科学专业，博士学位

2013.09-2017.12天津大学，制药工程专业，博士学位

2010.09-2013.07天津大学，生物化工专业，硕士学位

2005.09-2009.07天津大学，生物工程专业，本科学位

二、工作经历

2018.7-至今澳门永利集团3044，讲师

三、研究方向(包括承担课题项目)

1.小分子抗体药物的研究与开发

2.免疫学及肿瘤的免疫治疗

3.肠道微生物与机体紊乱之间的关系研究

四、近5年发表论文

1. Hu Y, Liu C,Muyldermans S. Nanobody-based delivery systems for diagnosis andtargeted tumor therapy. Frontiers in Immunology, 2017, 8:1442.

2. Hu Y, Romão E,Vertommen D, Vincke C, Morales-Yánez F, Gutiérrez C, Liu C,Muyldermans S. Generation of Nanobodies against SlyD and developmentof tools to eliminate this bacterial contaminant from recombinantproteins. Protein Expression and Purification, 2017, 137:64-76.

3. Hu Y, Liu J, HuangH. Recent agents targeting HIF-1alpha for cancer therapy. Journal ofCellular Biochemistry. 2013, 114:498-509.

4. Cawez F, Duray E,Hu Y, Vandenameele J, Romão E, Vincke C, Galleni M, Muyldermans S,Vandevenne M. Combinatorial design of a nanobody that specificallytargets structured RNAs. Journal of Molecular Biology, 2018, 11:1652-1670.

5. Romão E,Morales-Yánez F, Hu Y, Crauwels M, De Pauw P, Hassanzadeh GG,Devoogdt N, Ackaert C, Vincke C, Muyldermans S. Identification ofuseful nanobodies by phage display of immune single domain librariesderived from camelid heavy chain antibodies. Current PharmaceuticalDesign, 2016, 22:6500-6518.

6. Li M, Fan X, Liu J,Hu Y, Huang H. Selection by phage display of nanobodies directedagainst hypoxia inducible factor-1alpha (HIF-1alpha). AppliedBiochemistry and Biotechnology, 2015, 62:738-745.

7. Huang H, Song C,Yang Z, Dong Y, Hu Y, Gao F. Identification of the replicationorigins from Cyanothece ATCC 51142 and their interactions with theDnaA protein: from in silico to in vitro studies. Frontiers inMicrobiology, 2015, 6:1370.

8. Fan X, Hu Y, HuangH. Nanobodies: Novel biomedical vehicles in targeting tumor. Journalof Chemical and Pharmaceutical Research, 2014, 6:458-462.

五、荣誉和奖励

2017年，布鲁塞尔自由大学博士奖学金

2012年，硕士研究生国家奖学金

六、联系方式

1.通讯地址：天津市津南区同砚路38号

2.E-mail：yzhu@nankai.edu.cn